发明公开
- 专利标题： HUMANIZED ANTIBODIES THAT BIND TO CD19 AND THEIR USES
- 专利标题（中）： 人源化抗体TO CD19结合和用途
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申请号： EP10706363.8申请日： 2010-02-23
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公开(公告)号： EP2398829A2公开(公告)日： 2011-12-28
- 发明人: BLEIN, Stanislas , SKEGRO, Darko , DEBONNEVILLE, Christophe , BERTSCHINGER, Martin
- 申请人： Glenmark Pharmaceuticals S.A.
- 申请人地址： Chemin de Combetta, 5 2300 La Chaux-de-Fonds CH
- 专利权人： Glenmark Pharmaceuticals S.A.
- 当前专利权人： Glenmark Pharmaceuticals S.A.
- 当前专利权人地址： Chemin de Combetta, 5 2300 La Chaux-de-Fonds CH
- 代理机构： Schöllhorn, Andreas
- 优先权： US154524P 20090223
- 国际公布： WO2010095031 20100826
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
The present invention relates to humanized antibodies or fragments thereof that bind to human CD 19. More specifically, the present invention relates to a humanized antibody or fragment thereof that binds to human CD 19 comprising a heavy chain CDRl comprising the amino acid sequence of SEQ ID NO: 27, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 28, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 29; and/or comprising a light chain CDRl comprising the amino acid sequence of SEQ ID NO: 30, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 31 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 32.
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