发明公开
EP2403524A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 24P4C12 PROTEINS
审中-公开
AN 24P4C12结合的蛋白质的抗体药物偶联物（ADC）
- 专利标题： ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 24P4C12 PROTEINS
- 专利标题（中）： AN 24P4C12结合的蛋白质的抗体药物偶联物（ADC）
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申请号： EP10756560.8申请日： 2010-03-05
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公开(公告)号： EP2403524A1公开(公告)日： 2012-01-11
- 发明人: GUDAS, Jean , JAKOBOVITS, Aya , AN, Zili , MORRISON, Robert, Kendall , MORRISON, Karen, Jane Meyrick , JIA, Xiao-Chi , BENJAMIN, Dennis , MOSER, Ruth , SENTER, Peter
- 申请人： Agensys, Inc. , Seattle Genetics, Inc.
- 申请人地址： 2225 Colorado Boulevard Santa Monica, CA 90404 US
- 专利权人： Agensys, Inc.,Seattle Genetics, Inc.
- 当前专利权人： Agensys, Inc.,Seattle Genetics, Inc.
- 当前专利权人地址： 2225 Colorado Boulevard Santa Monica, CA 90404 US
- 代理机构： Irvine, Jonquil Claire
- 优先权： US158143P 20090306
- 国际公布： WO2010111018 20100930
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C12P21/08
摘要：
Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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