发明公开
- 专利标题： AGENTS DE RETICULATION
- 专利标题（英）： Cross-linking agents
- 专利标题（中）： 交联剂
-
申请号： EP10707893.3申请日： 2010-03-04
-
公开(公告)号： EP2403829A1公开(公告)日： 2012-01-11
- 发明人: MARTINEZ, Jean , SUBRA, Gilles , GOUBET, Christine , PARAMELLE, David , FOREST, Eric , HEYMANN, Michaël , GEOURJON, Christophe
- 申请人： Centre National de la Recherche Scientifique CNRS , Université de Montpellier I , Université Montpellier 2 Sciences et Techniques
- 申请人地址： 3, rue Michel Ange 75016 Paris FR
- 专利权人： Centre National de la Recherche Scientifique CNRS,Université de Montpellier I,Université Montpellier 2 Sciences et Techniques
- 当前专利权人： Centre National de la Recherche Scientifique CNRS,Université de Montpellier I,Université Montpellier 2 Sciences et Techniques
- 当前专利权人地址： 3, rue Michel Ange 75016 Paris FR
- 代理机构： Ahner, Francis
- 优先权： EP09305201 20090304
- 国际公布： WO2010100238 20100910
- 主分类号： C07D207/46
- IPC分类号： C07D207/46
摘要：
The invention relates to a protein cross-linking agent of the formula, where R
1 is an aryl group optionally substituted once or several times by a grouping selected from the group consisting of hydroxy, C
1 -C
4 alkyl, OBoc, SO
3 Na, Deu, and C
1 -C
4 alkoxy groupings, R
2 is N, (III), or (IV), n and m are identical or different integers between 0 and 10, p is an integer between 0 and 5, k is 0, 1, 2 or 3, and X and X' are identical or different and are a reactive function of the proteins. The invention also relates to a method for the structural analysis of a protein or a protein complex.
1 is an aryl group optionally substituted once or several times by a grouping selected from the group consisting of hydroxy, C
1 -C
4 alkyl, OBoc, SO
3 Na, Deu, and C
1 -C
4 alkoxy groupings, R
2 is N, (III), or (IV), n and m are identical or different integers between 0 and 10, p is an integer between 0 and 5, k is 0, 1, 2 or 3, and X and X' are identical or different and are a reactive function of the proteins. The invention also relates to a method for the structural analysis of a protein or a protein complex.
信息查询
