发明公开
EP2407548A1 Molecules with reduced half-lives, compositions and uses thereof
审中-公开
Molekülemit reduzierter Halbwertzeit，Zusammensetzungen und ihre Verwendung
- 专利标题： Molecules with reduced half-lives, compositions and uses thereof
- 专利标题（中）： Molekülemit reduzierter Halbwertzeit，Zusammensetzungen und ihre Verwendung
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申请号： EP11179956.5申请日： 2007-10-16
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公开(公告)号： EP2407548A1公开(公告)日： 2012-01-18
- 发明人: Dall'Acqua, William , Wu, Herren
- 申请人： MedImmune, LLC
- 申请人地址： One MedImmune Way Gaithersburg, MD 20878 US
- 专利权人： MedImmune, LLC
- 当前专利权人： MedImmune, LLC
- 当前专利权人地址： One MedImmune Way Gaithersburg, MD 20878 US
- 代理机构： Myers, Jonathan David
- 优先权： US851739P 20061016
- 主分类号： C12P21/08
- IPC分类号： C12P21/08
摘要：
The present invention provides polypeptides containing at least the FcRn binding portion of an Fc region of an immunoglobulin molecule and that have altered amino acid sequences relative to wild type immunoglobulin molecules. The polypeptides have decreased in vivo serum half-lives and can be employed in various methods.
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