The invention relates to an irradiation-cooling combination for application in photodynamic therapy having an irradiation element (120), a cooling element (130) permeable by the emitted radiation in an irradiation pass-through direction, wherein said cooling element is designed for attachment between the irradiation element (120) and a treatment surface (160) of a patient. The cooling element (130) has an optical pass-through surface that can be cooled as an attachment to the treatment surface (160). Additional components of the invention are a first fastening device (150) for defined positioning of the irradiation-cooling combination opposite the treatment surface (160), a second fastening device (140) for attaching the irradiation element (120) on the cooling element (130), a control unit (110) and a power supply (100). The invention provides effective pain management during photodynamic therapy in connection with a mobile treatment system and larger treatment areas by means of a uniform radiation field.