发明授权
EP2417165B1 METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SHIGA TOXIN-PRODUCING ESCHERICHIA COLI INFECTION
有权
方法和组合物可用于治疗和预防滋贺县生产大肠杆菌感染
- 专利标题： METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SHIGA TOXIN-PRODUCING ESCHERICHIA COLI INFECTION
- 专利标题（中）： 方法和组合物可用于治疗和预防滋贺县生产大肠杆菌感染
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申请号： EP10761153.5申请日： 2010-04-06
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公开(公告)号： EP2417165B1公开(公告)日： 2016-05-25
- 发明人: POTTER, Andrew, A. , ASPER, David , ROGAN, Dragan
- 申请人： UNIVERSITY OF SASKATCHEWAN
- 申请人地址： 120 Veterinary Road Saskatoon, Saskatchewan S7N 5E3 CA
- 专利权人： UNIVERSITY OF SASKATCHEWAN
- 当前专利权人： UNIVERSITY OF SASKATCHEWAN
- 当前专利权人地址： 120 Veterinary Road Saskatoon, Saskatchewan S7N 5E3 CA
- 代理机构： D Young & Co LLP
- 优先权： US211989P 20090406; US216608P 20090519
- 国际公布： WO2010115278 20101014
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; A61K39/108 ; A61K39/385 ; A61P31/04 ; A61P37/04 ; C07K14/245
摘要：
Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein comprising more than one epitope of an immunogenic STEC protein from more than one STEC serotype. Additional compositions include at least two purified STEC proteins, wherein the STEC proteins are selected from a full-length STEC protein, an immunogenic fragment or variant thereof, wherein at least one of the STEC proteins generates antibodies that react with STEC O157 and at least one other STEC serotype.
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