A method of dynamic resource transaction in wireless OFDMA systems is proposed. In macro-femto overlay network architecture, network and traffic condition varies dynamically. Dynamic resource transaction is a powerful mechanism to achieve effective interference mitigation and flexible radio resource management to enhance resource utilization as well as to improve link performance. Dynamic resource transaction can be performed by signaling or message exchange through backhaul network or air-interface connections. The signal or message through backhaul network can be directly exchanged among multiple base stations or be routed through a centralized self-organizing network (SON) server. In one embodiment, dynamic resource transaction is used to achieve adaptive reservation region configuration, a solution to avoid interference and frequent handover for highspeed mobile stations.