发明公开
- 专利标题： ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS
- 专利标题（中）： 作为GABA调节剂的异恶唑 - 吡啶衍生物
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申请号： EP10715849.5申请日： 2010-04-28
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公开(公告)号： EP2427457A1公开(公告)日： 2012-03-14
- 发明人: BUETTELMANN, Bernd , JAKOB-ROETNE, Roland , KNUST, Henner , LUCAS, Matthew C. , THOMAS, Andrew
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Salud, Carlos E.
- 优先权： EP09159631 20090507
- 国际公布： WO2010127978 20101111
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; C07D413/14 ; A61K31/4439 ; A61P25/00 ; A61P25/18 ; A61P25/22 ; A61P25/28
摘要：
The present invention is concerned with novel isoxazole derivatives of formula (I) wherein X, R
1 , R
2 , R
3 and R
4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula (I), pharmaceutical compositions containing them and their use as medicaments.
1 , R
2 , R
3 and R
4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula (I), pharmaceutical compositions containing them and their use as medicaments.
公开/授权文献
- EP2427457B1 ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS 公开/授权日：2013-07-17
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