发明公开
- 专利标题： METHOD FOR PREPARING D-BIOTIN
- 专利标题（中）： 制备D-生物素的方法
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申请号： EP10777372.3申请日： 2010-05-20
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公开(公告)号： EP2433942A1公开(公告)日： 2012-03-28
- 发明人: PAN, Yajin , PI, Shiqing , DING, Wenzhen , GU, Lixin , WEI, Angfeng , HE, Yimin
- 申请人： Zhejiang Medicine Co., Ltd.
- 申请人地址： Xinchang Pharmaceutical Factory No 59 East Huancheng Road. Xinchang County Town Shaoxing, Zhejiang 312500 CN
- 专利权人： Zhejiang Medicine Co., Ltd.
- 当前专利权人： Zhejiang Medicine Co., Ltd.
- 当前专利权人地址： Xinchang Pharmaceutical Factory No 59 East Huancheng Road. Xinchang County Town Shaoxing, Zhejiang 312500 CN
- 代理机构： Schmid, Klaus Michael Johannes
- 优先权： CN200910098678 20090521
- 国际公布： WO2010133169 20101125
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; C07D235/00 ; C07D333/00
摘要：
An Improved Preparation Method for D-Biotin
The invention discloses an improved preparation method for D-Biotin. If the composite method takes the diesteas the raw material, the finial biotin will be generated with impurities. The features of the invention refers to the improved preparation method for D-Biotin includes: firstly, (3aS,4S,6aR)-1,3-ωωω -butyl)-1 H -thiaphene[3,4-d]-2,4(1 H) -ketone is got after the methane tricarboxylic acid trialkyl ester and (3aR, 8aS, 8bS)-1,3-2-[3,4-d]thiophene [1,2-a]sulfuryl halide have the condensation reaction in the alkaline environment and then D-Biotin can be got after the reaction process of hydrolysis, decarbaxylation and closed loop. The invention succeeds in greatly improving the biotin quality from the original basis and simultaneously avoids the generation of impurities and the occurrence of side reaction.
The invention discloses an improved preparation method for D-Biotin. If the composite method takes the diesteas the raw material, the finial biotin will be generated with impurities. The features of the invention refers to the improved preparation method for D-Biotin includes: firstly, (3aS,4S,6aR)-1,3-ωωω -butyl)-1 H -thiaphene[3,4-d]-2,4(1 H) -ketone is got after the methane tricarboxylic acid trialkyl ester and (3aR, 8aS, 8bS)-1,3-2-[3,4-d]thiophene [1,2-a]sulfuryl halide have the condensation reaction in the alkaline environment and then D-Biotin can be got after the reaction process of hydrolysis, decarbaxylation and closed loop. The invention succeeds in greatly improving the biotin quality from the original basis and simultaneously avoids the generation of impurities and the occurrence of side reaction.
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