发明公开
EP2433943A1 Thienopyrazole derivatives having PDE7 inhibitory activity
有权
ZienisproduktefürThienopyrazol-Derivate mit PDE7-hemmender Wirkung
- 专利标题： Thienopyrazole derivatives having PDE7 inhibitory activity
- 专利标题（中）： ZienisproduktefürThienopyrazol-Derivate mit PDE7-hemmender Wirkung
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申请号： EP11179011.9申请日： 2005-07-01
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公开(公告)号： EP2433943A1公开(公告)日： 2012-03-28
- 发明人: Inoue, Hidekazu , Murafuji, Hidenobu , Hayashi, Yasuhiro
- 申请人： Daiichi Sankyo Company, Limited
- 申请人地址： 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo JP
- 专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人地址： 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo JP
- 代理机构： Beckmann, Claus
- 优先权： JP2004195836 20040701
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; C07D519/00 ; A61K31/4162 ; A61P37/00
摘要：
To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I):
[wherein, especially, R 1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R 2 is methyl; R 3 is a hydrogen atom; and R 4 is a group: -CONR 5 R 6 (in which any one of R 5 and R 6 is a hydrogen atom)].
[wherein, especially, R 1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R 2 is methyl; R 3 is a hydrogen atom; and R 4 is a group: -CONR 5 R 6 (in which any one of R 5 and R 6 is a hydrogen atom)].
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