发明公开
- 专利标题： THERAPEUTIC AND DIAGNOSTIC MOLECULES
- 专利标题（中）： 治疗和诊断分子
-
申请号： EP10782840.2申请日： 2010-06-04
-
公开(公告)号： EP2438167A1公开(公告)日： 2012-04-11
- 发明人: GAMBLE, Jennifer , VADAS, Mathew , GOODALL, Gregory , YOUNG, Jennifer
- 申请人： Centenary Institute Of Cancer Medicine And Cell Biology , The University Of Sydney , MEDVET SCIENCE PTY. LTD. , Wenkart Foundation
- 申请人地址： Building 93, Royal Prince Alfred Hospital Missenden Road Camperdown, New South Wales 2050 AU
- 专利权人： Centenary Institute Of Cancer Medicine And Cell Biology,The University Of Sydney,MEDVET SCIENCE PTY. LTD.,Wenkart Foundation
- 当前专利权人： Centenary Institute Of Cancer Medicine And Cell Biology,The University Of Sydney,MEDVET SCIENCE PTY. LTD.,Wenkart Foundation
- 当前专利权人地址： Building 93, Royal Prince Alfred Hospital Missenden Road Camperdown, New South Wales 2050 AU
- 代理机构： Marcadé, Véronique
- 优先权： AU2009902615 20090605
- 国际公布： WO2010139026 20101209
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61P9/10 ; C07H21/02 ; A61K48/00 ; A61P35/00
摘要：
The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.
公开/授权文献
- EP2438167B1 THERAPEUTIC AND DIAGNOSTIC MOLECULES 公开/授权日：2017-07-26
信息查询
IPC分类:
