Described herein is a multi-channel biopotential signal acquisition system (900) in which a plurality of biopotential channels is corrected for common-mode interference. Each biopotential channel comprises an electrode (910, 920, 930, 940) for providing a biopotential input signal and an associated amplifier (950, 960, 970, 980) for amplifying the biopotential input signal and for providing a biopotential output signal (955, 965, 975, 985) that is processed in a processor (250, 260, 270, 990). Each biopotential output signal (955, 965, 975, 985) is passed to a common-mode feedback system (810) that determines an average common-mode signal and feeds that signal back to each of the amplifiers (950, 960, 970, 980) in each of the biopotential channels to enhance common-mode rejection ratio of the system (900).