发明公开
EP2450031A1 METHOD FOR PRODUCING LIPOSOMES BY TWO-STAGE EMULSIFICATION METHOD USING OUTER AQUEOUS PHASE CONTAINING SPECIFIC DISPERSING AGENT, METHOD FOR PRODUCING LIPOSOME DISPERSION OR DRY POWDER THEREOF USING THE METHOD FOR PRODUCING LIPOSOMES, AND LIPOSOME DISPERSION OR DRY POWDER THEREOF PRODUCED THEREBY
审中-公开
用于生产脂质体通过两阶段的乳化使用具有特定的分散剂,工艺用于生产脂质体或干粉BY使用生产脂质和脂质体或干粉的方法外水其相位
- 专利标题: METHOD FOR PRODUCING LIPOSOMES BY TWO-STAGE EMULSIFICATION METHOD USING OUTER AQUEOUS PHASE CONTAINING SPECIFIC DISPERSING AGENT, METHOD FOR PRODUCING LIPOSOME DISPERSION OR DRY POWDER THEREOF USING THE METHOD FOR PRODUCING LIPOSOMES, AND LIPOSOME DISPERSION OR DRY POWDER THEREOF PRODUCED THEREBY
- 专利标题(中): 用于生产脂质体通过两阶段的乳化使用具有特定的分散剂,工艺用于生产脂质体或干粉BY使用生产脂质和脂质体或干粉的方法外水其相位
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申请号: EP10793951.4申请日: 2010-06-02
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公开(公告)号: EP2450031A1公开(公告)日: 2012-05-09
- 发明人: MOTOKUI, Yasuyuki , WADA, Takeshi , ISODA, Takeshi
- 申请人: Konica Minolta Holdings, Inc.
- 申请人地址: 1-6-1, Marunouchi Chiyoda-ku Tokyo 100-0005 JP
- 专利权人: Konica Minolta Holdings, Inc.
- 当前专利权人: Konica Minolta Holdings, Inc.
- 当前专利权人地址: 1-6-1, Marunouchi Chiyoda-ku Tokyo 100-0005 JP
- 代理机构: Gille Hrabal
- 优先权: JP2009157626 20090702
- 国际公布: WO2011001780 20110106
- 主分类号: A61K9/127
- IPC分类号: A61K9/127 ; A61K8/14 ; A61K9/10 ; A61K9/113 ; A61K9/14 ; A61K47/34 ; A61K47/36 ; A61K47/42 ; A61Q19/00
摘要:
Disclosed is a method for producing liposomes, a liposome dispersion or a dry powder thereof by a two-stage emulsification method using an additive (dispersing agent) whereby a liposome dispersion and a dry powder thereof, which ensure the prevention of the leakage of an encapsulated drug or the like from liposomes during prolonged storage and can be stably used over a long period of time, can be obtained. A method for producing liposomes by a two-stage emulsification method, characterized by using, in the secondary emulsification step, an outer aqueous phase containing a dispersing agent (hereinafter referred to as "a specific dispersing agent") which forms no molecular self-assembly or exclusively forms molecular self-assemblies having a volume-average particle diameter equal to or less than 10 nm; and a method for producing a liposome dispersion and a dry powder thereof using the aforesaid production method. The aforesaid specific dispersing agent preferably contains at least one component selected from among, for example, gelatin, albumin, dextran and a polyalkylene oxide-based compound.
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