发明公开
- 专利标题： Compositions and methods for the delivery of oxygen
- 专利标题（中）： 用于输送氧气的组合物和方法
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申请号： EP11189808.6申请日： 2007-05-21
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公开(公告)号： EP2463295A1公开(公告)日： 2012-06-13
- 发明人: Cary, Stephen P.L. , Boon, Elizabeth M. , Weinert, Emily , Winger, Jonathan A. , Marletta, Michael A.
- 申请人： The Regents of The University of California
- 申请人地址： 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 US
- 专利权人： The Regents of The University of California
- 当前专利权人： The Regents of The University of California
- 当前专利权人地址： 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 US
- 代理机构： Smith, Stephen Edward
- 优先权： US921505P 20060522
- 主分类号： C07K14/00
- IPC分类号： C07K14/00
摘要：
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O 2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O 2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O 2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O 2 is beneficial.
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