发明公开
- 专利标题： INHIBITORS OF JNK
- 专利标题（中）： JNK的抑制剂
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申请号： EP10739948.7申请日： 2010-08-06
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公开(公告)号： EP2464640A1公开(公告)日： 2012-06-20
- 发明人: GONG, Leyi , HAN, Xiaochun , MAKRA, Ferenc , PALMER, Wylie Solang , RAPTOVA, Lubica
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Schirlin, Julien
- 优先权： US232522P 20090810
- 国际公布： WO2011018417 20110217
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D401/14 ; A61K31/506 ; A61P29/00 ; A61P25/00 ; A61P35/00
摘要：
The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein p, q, Y', r, R
1 , R
2 , X, X
1 , X
2 , X
3 , and X
4 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
1 , R
2 , X, X
1 , X
2 , X
3 , and X
4 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
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