发明公开
EP2480077A1 NOVEL PYRROLIDINES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE
有权
吡咯烷ALS胰高血糖素受体拮抗剂，其组合物及使用方法
- 专利标题： NOVEL PYRROLIDINES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE
- 专利标题（中）： 吡咯烷ALS胰高血糖素受体拮抗剂，其组合物及使用方法
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申请号： EP10819272.5申请日： 2010-09-16
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公开(公告)号： EP2480077A1公开(公告)日： 2012-08-01
- 发明人: GILBERT, Eric, J. , MILLER, Michael, W. , DEMONG, Duane Eugene , STAMFORD, Andrew, W. , GREENLEE, William, J.
- 申请人： Schering Corporation
- 申请人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033 US
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033 US
- 代理机构： Jaap, David Robert
- 优先权： US244762P 20090922
- 国际公布： WO2011037815 20110331
- 主分类号： A01N43/36
- IPC分类号： A01N43/36 ; A61K31/40
摘要：
The present invention relates to compounds of the general formula: (I) wherein ring B, R
1, R
2 , R
3 , Z, and L
1 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.
1, R
2 , R
3 , Z, and L
1 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.
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