发明公开
EP2492274A1 2,4,6- OR 2,6-ALKOXYPHENYL DIALKYLPHOSPHINE, TETRAFLUOROBORATE, PREPARATION METHOD AND USE THEREOF
有权
2,4,6-或2,6-烷氧基苯基二烷基膦，四氟硼酸盐，制备方法及其用途
- 专利标题： 2,4,6- OR 2,6-ALKOXYPHENYL DIALKYLPHOSPHINE, TETRAFLUOROBORATE, PREPARATION METHOD AND USE THEREOF
- 专利标题（中）： 2,4,6-或2,6-烷氧基苯基二烷基膦，四氟硼酸盐，制备方法及其用途
-
申请号： EP09850497.0申请日： 2009-12-21
-
公开(公告)号： EP2492274A1公开(公告)日： 2012-08-29
- 发明人: MA, Shengming , LV, Bo , FU, Chunling
- 申请人： Zhejiang University
- 申请人地址： No. 20, Yugu Road Xihu District Hangzhou, Zhejiang 310027 CN
- 专利权人： Zhejiang University
- 当前专利权人： Zhejiang University
- 当前专利权人地址： No. 20, Yugu Road Xihu District Hangzhou, Zhejiang 310027 CN
- 代理机构： Meyer-Dulheuer, Karl-Hermann
- 优先权： CN200910154029 20091022
- 国际公布： WO2011047501 20110428
- 主分类号： C07F9/50
- IPC分类号： C07F9/50 ; B01J31/24 ; C07C43/215 ; C07C41/30 ; C07D307/58
摘要：
The current invention relates to the structure, synthesis of dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, as well as its applications in the palladium catalyzed carbon-chlorine bond activation for Suzuki coupling reactions and carbon-nitrogen bond formation reactions. The dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate could coordinate with the palladium catalyst to activate the inert carbon-chlorine bond highly selectively and catalyze Suzuki coupling reaction with arylboronic acid or carbon-nitrogen bond formation reaction with organic amines. The current invention uses only one step to synthesize dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine and its tetrafluoroborate is stable in the air. Compared with known synthetic routes of ligands used in activating carbon-chlorine bonds, the method of current invention is short, easy to operate. Moreover, with this type of ligands, the Suzuki coupling products of optically active chlorolactones and arylboronic acids would maintain their configuration and optical purity.
公开/授权文献
信息查询
