发明公开
- 专利标题： Aripiprazole pamoate salt
- 专利标题（中）： 阿立哌唑双羟萘酸盐
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申请号： EP12165213.5申请日： 2004-07-29
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公开(公告)号： EP2497476A1公开(公告)日： 2012-09-12
- 发明人: Greco, Kristyn , Wright, James
- 申请人： Alkermes, Inc.
- 申请人地址： 852 Winter Street Waltham, MA 02451 US
- 专利权人： Alkermes, Inc.
- 当前专利权人： Alkermes, Inc.
- 当前专利权人地址： 852 Winter Street Waltham, MA 02451 US
- 代理机构： Chapman, Paul William
- 优先权： US635232 20030806
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/495 ; C07D211/52 ; C07D403/02 ; A61P25/18 ; A61K31/496
摘要：
The invention relates to the discovery that pamoate salt of aripiprazole results in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salt of aripiprazole. Preferably, the pamoate salt is characterized by a ratio of aripiprazole to pamoate of 1:1 or 2:1. The invention further relates to methods of treating an individual in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of aripiprazole.
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