- 专利标题： Genetically engineered swine influenza virus and uses thereof
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申请号： EP12163377.0申请日： 2005-06-01
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公开(公告)号： EP2497492B1公开(公告)日： 2018-08-08
- 发明人: Palese, Peter , Garcia-Sastre, Adolfo , Webby, Richard, J , Richt, Juergen, A. , Webster, Robert , Lager, Kelly, M.
- 申请人： Icahn School of Medicine at Mount Sinai , The United States of America as represented by the Secretary of Agriculture , St. Jude Children's Research Hospital
- 申请人地址： One Gustave L. Levy Place New York, NY 10029 US
- 专利权人： Icahn School of Medicine at Mount Sinai,The United States of America as represented by the Secretary of Agriculture,St. Jude Children's Research Hospital
- 当前专利权人： Icahn School of Medicine at Mount Sinai,The United States of America as represented by the Secretary of Agriculture,St. Jude Children's Research Hospital
- 当前专利权人地址： One Gustave L. Levy Place New York, NY 10029 US
- 代理机构： Jones Day
- 优先权： US576418P 20040601
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/12 ; A61K39/145 ; C12N15/64 ; C12N5/00 ; A61K39/116
摘要：
The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated swine influenza viruses having modifications to a swine NS1 gene that diminish or eliminate the ability of the NS 1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.
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