- 专利标题: MONOMERIC ANTIBODY FC
-
申请号: EP10832331.2申请日: 2010-11-22
-
公开(公告)号: EP2504360B1公开(公告)日: 2018-08-15
- 发明人: ZHOU, Hongxing , KANNAN, Gunasekaran , SUN, Nancy
- 申请人: Amgen Inc.
- 申请人地址: One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 专利权人: Amgen Inc.
- 当前专利权人: Amgen Inc.
- 当前专利权人地址: One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 代理机构: Care, Alison
- 优先权: US263730P 20091123
- 国际公布: WO2011063348 20110526
- 主分类号: C07K16/00
- IPC分类号: C07K16/00 ; C07H21/00 ; C12P21/08 ; C07K16/28 ; C07K16/36
摘要:
The invention relates to monomeric Fc polypeptides and methods of making and using such polypeptides. The polypeptides comprise substitution of one or more hydrophobic interface residues in the CH3 region with a polar amino acid.
公开/授权文献
- EP2504360A1 MONOMERIC ANTIBODY FC 公开/授权日:2012-10-03
信息查询