发明公开
EP2515661A4 IMMUNOPROTECTION BY ORAL ADMINISTRATION OF RECOMBINANT LACTOCOCCUS LACTIS MINI-CAPSULES
审中-公开
免疫保护BY MINI胶囊口服给药的重组与乳酸乳球菌
- 专利标题: IMMUNOPROTECTION BY ORAL ADMINISTRATION OF RECOMBINANT LACTOCOCCUS LACTIS MINI-CAPSULES
- 专利标题(中): 免疫保护BY MINI胶囊口服给药的重组与乳酸乳球菌
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申请号: EP10840176申请日: 2010-12-23
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公开(公告)号: EP2515661A4公开(公告)日: 2013-11-13
- 发明人: LAM DOMINIC MAN-KIT , XU YUHONG
- 申请人: VAXGENE CORP
- 专利权人: VAXGENE CORP
- 当前专利权人: VAXGENE CORP
- 优先权: US28966309 2009-12-23
- 主分类号: A61K39/145
- IPC分类号: A61K39/145 ; A61K39/00
摘要:
In one embodiment, the present invention provides for an edible mini-capsule form of live, non-persisting, recombinant Lactococcus lactis (L.lactis) vaccine against a pathogen such as the highly virulent influenza H5N1 strain. Enteric coated capsule of the present invention induced high levels of hemagglutinin-specific serum IgG and fecal IgA antibody production after oral administration in mice and chickens, and rendered complete protection against a lethal challenge of H5N1 virus in mice. The present invention thus demonstrates a broadly applicable platform technology for producing and administering edible vaccines against bacterial and viral infections.
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