发明公开
EP2520299A1 SOLID PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION
审中-公开
FESTE PHARMAZEUTISCHE ZUSAMMENSETZUNG ZUR ORALEN VERABREICHUNG
- 专利标题： SOLID PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION
- 专利标题（中）： FESTE PHARMAZEUTISCHE ZUSAMMENSETZUNG ZUR ORALEN VERABREICHUNG
-
申请号： EP10840973.1申请日： 2010-12-27
-
公开(公告)号： EP2520299A1公开(公告)日： 2012-11-07
- 发明人: KOZAKI, Masato , TANIZAWA, Yoshio
- 申请人： Kowa Co., Ltd.
- 申请人地址： 6-29, Nishiki 3-chome Naka-ku Nagoya-shi, Aichi 460-8625 JP
- 专利权人： Kowa Co., Ltd.
- 当前专利权人： Kowa Co., Ltd.
- 当前专利权人地址： 6-29, Nishiki 3-chome Naka-ku Nagoya-shi, Aichi 460-8625 JP
- 代理机构： Blodig, Wolfgang
- 优先权： US290736P 20091229
- 国际公布： WO2011081117 20110707
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K9/16 ; A61K9/20 ; A61K47/12 ; A61K47/22 ; A61P3/06 ; A61P9/10 ; A61P43/00
摘要：
The present invention relates to a solid pharmaceutical composition for oral administration, containing the following components (A) and (B): (A)
2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4 -bis(methylthio)-6-methyl-3-pyridyl]acetamide (compound a) or an acid addition salt thereof, and (B) organic acid selected from the group consisting of tartaric acid, malic acid, ascorbic acid and benzoic acid. An improvement is achieved in the dissolubility of the compound a, which is useful as a therapeutic agent for hypercholesterolemia, arteriosclerosis, and the like.
2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4 -bis(methylthio)-6-methyl-3-pyridyl]acetamide (compound a) or an acid addition salt thereof, and (B) organic acid selected from the group consisting of tartaric acid, malic acid, ascorbic acid and benzoic acid. An improvement is achieved in the dissolubility of the compound a, which is useful as a therapeutic agent for hypercholesterolemia, arteriosclerosis, and the like.
信息查询
IPC分类:
