发明授权
- 专利标题： Inhibitors of bruton's tyrosine kinase
- 专利标题（中）： Hammer der Bruton-Tyrosinkinase
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申请号： EP12166300.9申请日： 2006-12-28
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公开(公告)号： EP2526771B1公开(公告)日： 2016-11-30
- 发明人: Honigberg, Lee , Verner, Erik , Pan, Zhengying
- 申请人： Pharmacyclics LLC
- 申请人地址： 995 East Arques Avenue Sunnyvale, CA 94085 US
- 专利权人： Pharmacyclics LLC
- 当前专利权人： Pharmacyclics LLC
- 当前专利权人地址： 995 East Arques Avenue Sunnyvale, CA 94085 US
- 代理机构： Cole, William Gwyn
- 优先权： US826720P 20060922; US828590P 20061006
- 主分类号： A01N43/90
- IPC分类号： A01N43/90 ; A61K31/519 ; C07D487/04 ; A61P35/00
摘要：
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described arc irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
公开/授权文献
- EP2526771A1 Inhibitors of bruton's tyrosine kinase 公开/授权日：2012-11-28
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