发明公开
- 专利标题: SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME
- 专利标题(中): 生产合成中间体恶唑和过程
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申请号: EP11706939.3申请日: 2011-01-28
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公开(公告)号: EP2528896A1公开(公告)日: 2012-12-05
- 发明人: YAMAMOTO, Akihiro , SHINHAMA, Koichi , FUJITA, Nobuhisa , AKI, Shinji , OGASAWARA, Shin , UTSUMI, Naoto
- 申请人: Otsuka Pharmaceutical Co., Ltd.
- 申请人地址: 9, Kanda-Tsukasa-machi 2-chome Chiyoda-ku Tokyo 101-8535 JP
- 专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址: 9, Kanda-Tsukasa-machi 2-chome Chiyoda-ku Tokyo 101-8535 JP
- 代理机构: HOFFMANN EITLE
- 优先权: JP2010019289 20100129
- 国际公布: WO2011093529 20110804
- 主分类号: C07D211/46
- IPC分类号: C07D211/46 ; C07D405/12 ; C07D498/04
摘要:
An object of the present invention is to provide a method for producing an oxazole compound in a high yield. The object can be achieved by a compound represented by Formula (11): wherein R
1 is a hydrogen atom or lower-alkyl group; R
2 is a 1-piperidyl group substituted at the 4-position with a substituent selected from (A1a) a phenoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1b) a phenoxy-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkyl groups, (A1c) a phenyl-substituted lower-alkoxy lower-alkyl group substituted on the phenyl moiety with halogen, (A1d) a phenyl-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1e) an amino group substituted with a phenyl group substituted with one or more halogen-substituted lower-alkoxy groups, and a lower-alkyl group, and (A1f) a phenyl-substituted lower-alkoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups; n is an integer from 1 to 6; and X
3 is an organic sulfonyloxy group.
1 is a hydrogen atom or lower-alkyl group; R
2 is a 1-piperidyl group substituted at the 4-position with a substituent selected from (A1a) a phenoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1b) a phenoxy-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkyl groups, (A1c) a phenyl-substituted lower-alkoxy lower-alkyl group substituted on the phenyl moiety with halogen, (A1d) a phenyl-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1e) an amino group substituted with a phenyl group substituted with one or more halogen-substituted lower-alkoxy groups, and a lower-alkyl group, and (A1f) a phenyl-substituted lower-alkoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups; n is an integer from 1 to 6; and X
3 is an organic sulfonyloxy group.
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