发明公开
- 专利标题： PROCESSES OF SYNTHESIZING DIHYDROPYRIDOPHTHALAZINONE DERIVATIVES
- 专利标题（中）： 合成二氢吡啶并哒嗪酮衍生物的过程
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申请号： EP11740513.4申请日： 2011-02-08
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公开(公告)号： EP2533640A1公开(公告)日： 2012-12-19
- 发明人: WANG, Bing , CHU, Daniel , LIU, Yongbo , JIANG, Quan , LU, Lei
- 申请人： BioMarin Pharmaceutical Inc.
- 申请人地址： 105 Digital Drive Novato, CA 94949 US
- 专利权人： BioMarin Pharmaceutical Inc.
- 当前专利权人： BioMarin Pharmaceutical Inc.
- 当前专利权人地址： 105 Digital Drive Novato, CA 94949 US
- 代理机构： Ritter, Thomas Kurt
- 优先权： US302457P 20100208
- 国际公布： WO2011097602 20110811
- 主分类号： A01N43/58
- IPC分类号： A01N43/58
摘要：
Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.
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