发明公开
EP2534240A4 YEAST MICROORGANISMS WITH REDUCED BY-PRODUCT ACCUMULATION FOR IMPROVED PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS
审中-公开
具有减少，产品集聚酵母微生物为燃料，化学品和氨基酸提高了生产
- 专利标题： YEAST MICROORGANISMS WITH REDUCED BY-PRODUCT ACCUMULATION FOR IMPROVED PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS
- 专利标题（中）： 具有减少，产品集聚酵母微生物为燃料，化学品和氨基酸提高了生产
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申请号： EP11780955申请日： 2011-02-11
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公开(公告)号： EP2534240A4公开(公告)日： 2014-04-16
- 发明人: BUELTER THOMAS , HAWKINS ANDREW , PORTER-SCHEINMAN STEPHANIE , MEINHOLD PETER , DUNDON CATHERINE ASLESON , ARISTIDOU ARISTOS , URANO JUN , LIES DOUG , PETERS MATTHEW , DEY MELISSA , JANCAUSKAS JUSTAS , BERRY RUTH , EVANS KENT , KELLY JULIE , BASTIAN SABINE , ARNOLD FRANCES
- 申请人： GEVO INC , CALIFORNIA INST OF TECHN
- 专利权人： GEVO INC,CALIFORNIA INST OF TECHN
- 当前专利权人： GEVO INC,CALIFORNIA INST OF TECHN
- 优先权： US201161430801 2011-01-07; US41188510 2010-11-09; US35213310 2010-06-07; US28264110 2010-03-10; US30856810 2010-02-26; US30406910 2010-02-12
- 主分类号： C12N1/00
- IPC分类号： C12N1/00 ; C12N1/18 ; C12N9/02 ; C12P7/16
摘要：
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
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