发明公开
EP2543375A1 Pyrrolo-pyrimidine analogues as inhibitors of bruton's tyrosine kinase
审中-公开
吡咯并嘧啶Analoga als Hemmer der Bruton-Tyrosinkinase
- 专利标题： Pyrrolo-pyrimidine analogues as inhibitors of bruton's tyrosine kinase
- 专利标题（中）： 吡咯并嘧啶Analoga als Hemmer der Bruton-Tyrosinkinase
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申请号： EP12172840.6申请日： 2008-03-27
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公开(公告)号： EP2543375A1公开(公告)日： 2013-01-09
- 发明人: Honigberger, Lee , Verner, Erik , Buggy, Joseph J. , Loury, David , Chen, Wei
- 申请人： Pharmacyclics, Inc.
- 申请人地址： 995 East Arques Avenue Sunnyvale, CA 94086 US
- 专利权人： Pharmacyclics, Inc.
- 当前专利权人： Pharmacyclics, Inc.
- 当前专利权人地址： 995 East Arques Avenue Sunnyvale, CA 94086 US
- 代理机构： Cole, William Gwyn
- 优先权： US692870 20070328; US964285 20071226; US17125P 20071227
- 主分类号： A61K31/52
- IPC分类号： A61K31/52 ; A61P29/00 ; A61P35/00 ; A61K31/519 ; C07D253/06 ; C07D487/04 ; C07D473/34 ; C07D471/04
摘要：
Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.
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