发明公开
EP2547685A1 SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS
审中-公开
螺旋 - 四环素RINGVERBINDUNGEN ALS BET-SEKRETASE-MODULATOREN
- 专利标题： SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS
- 专利标题（中）： 螺旋 - 四环素RINGVERBINDUNGEN ALS BET-SEKRETASE-MODULATOREN
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申请号： EP11710372.1申请日： 2011-03-14
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公开(公告)号： EP2547685A1公开(公告)日： 2013-01-23
- 发明人: CHENG, Yuan , WHITE, Ryan , AMEGADZIE, Albert , BROWN, James , CHENG, Alan, C. , DIMAURO, Erin, F. , DINEEN, Thomas , GORE, Vijay Keshav , HUMAN, Jason, Brooks , JUDD, Ted , KREIMAN, Charles , LIU, Qingyian , LOPEZ, Patricia , MA, Vu, Van , MARX, Isaac , MINATTI, Ana, Elena , NGUYEN, Hanh, Nho , PARAS, Nick, A. , PATEL, Vinod, F. , QIAN, Wenyuan , WEISS, Matthew , XUE, Qiufen , ZHENG, Xiao Mei , ZHONG, Wenge , EPSTEIN, Oleg
- 申请人： Amgen Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权： US314129P 20100315
- 国际公布： WO2011115938 20110922
- 主分类号： C07D498/10
- IPC分类号： C07D498/10 ; C07D498/20 ; C07D513/10 ; A61K31/424 ; A61K31/429 ; A61P25/28
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula (I) wherein A
1 , A
2 , A
3 , A
4 , A
5 , A
6 , R
2 , R
7 , X and Y of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
1 , A
2 , A
3 , A
4 , A
5 , A
6 , R
2 , R
7 , X and Y of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
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