发明授权
EP2547695B1 TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEIN CLDN18.2
有权
涉及自身蛋白CLDN18.2的体液免疫应答的肿瘤疫苗
- 专利标题： TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEIN CLDN18.2
- 专利标题（中）： 涉及自身蛋白CLDN18.2的体液免疫应答的肿瘤疫苗
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申请号： EP11707355.1申请日： 2011-03-09
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公开(公告)号： EP2547695B1公开(公告)日： 2018-05-09
- 发明人: KLAMP, Thorsten , SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HILLER, Thomas , SCHUMACHER, Jens
- 申请人： Biontech Protein Therapeutics GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 申请人地址： An der Goldgrube 12 55131 Mainz DE
- 专利权人： Biontech Protein Therapeutics GmbH,TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 当前专利权人： Biontech Protein Therapeutics GmbH,TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 当前专利权人地址： An der Goldgrube 12 55131 Mainz DE
- 代理机构： Schnappauf, Georg
- 优先权： EP10016216 20101230; EP10002775 20100316
- 国际公布： WO2011113546 20110922
- 主分类号： C07K14/02
- IPC分类号： C07K14/02 ; A61K39/29 ; C07K14/47 ; A61K39/00 ; C07K14/005 ; C12N7/00 ; A61P35/04
摘要：
The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
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