发明公开
EP2554660A1 INTERVERTEBRAL DISC NUCLEUS PULPOSUS STEM/PROGENITOR CELL, METHOD FOR CULTURING SAME, AND APPLICATION
审中-公开
BAND DISCS-髓核家长/及其使用PRE细胞培养和方法
- 专利标题： INTERVERTEBRAL DISC NUCLEUS PULPOSUS STEM/PROGENITOR CELL, METHOD FOR CULTURING SAME, AND APPLICATION
- 专利标题（中）： BAND DISCS-髓核家长/及其使用PRE细胞培养和方法
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申请号： EP11762825.5申请日： 2011-03-29
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公开(公告)号： EP2554660A1公开(公告)日： 2013-02-06
- 发明人: SAKAI, Daisuke , MOCHIDA, Joji , ANDO, Kiyoshi , NAKAMURA, Yoshihiko
- 申请人： Tokai University Educational System
- 申请人地址： 28-4 Tomigaya 2-chome Shibuya-ku Tokyo 151-0063 JP
- 专利权人： Tokai University Educational System
- 当前专利权人： Tokai University Educational System
- 当前专利权人地址： 28-4 Tomigaya 2-chome Shibuya-ku Tokyo 151-0063 JP
- 代理机构： Leathley, Anna Elisabeth
- 优先权： JP2010077743 20100330
- 国际公布： WO2011122601 20111006
- 主分类号： C12N5/077
- IPC分类号： C12N5/077 ; A61K35/28 ; A61K38/00 ; A61P19/00 ; C12N5/0775
摘要：
The purpose of the present invention is to provide intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. The present invention provides an intervertebral disk nucleus pulposus cell characterized by being isolated from the intervertebral disk nucleus pulposus of a vertebrate and being positive for at least one surface marker from among Tie2 and GD2. That is, the present invention provides an intervertebral disk nucleus pulposus stem cell characterized by being at least Tie2-positive for the surface marker and possessing self-renewal ability as well as multipotency capable of differentiating into adipocytes, osteocytes, chondrocytes and neurons. The present invention also provides an intervertebral disk nucleus pulposus progenitor cell characterized by being at least Tie2-negative and GD2-positive for the surface marker and capable of differentiating into any of adipocytes, osteocytes, chondrocytes and neurons.
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