Support structure to make instruments for dental prosthesis, comprising a base element (10), and a plurality of upper elements (20, 30, 50) which can be coupled through guide means (11, 12) with said base element (10) and positioning means (21, 31, 51) placed on each of said upper elements (20, 30, 50), one or more handmade articles need to make a dental prosthesis being assembled upon the instruments (A, V, P) resulting from said coupling. Said guide means include at least two first rods (11), positioned in respective first seats (19a) made along a perimeter portion of said base element (10), and at least one third rod (12) positioned in at least a respective second seat (19b) which is located substantially adjacent or opposite to the minimum perimeter portion of said base element (10) included between said first seats (19a).