发明公开
EP2560645A2 NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS
有权
KONJUGATE VON CC-1065 ANALOGA UND BIFUNKELLELLEN LINKERN
- 专利标题： NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS
- 专利标题（中）： KONJUGATE VON CC-1065 ANALOGA UND BIFUNKELLELLEN LINKERN
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申请号： EP11720340.6申请日： 2011-04-21
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公开(公告)号： EP2560645A2公开(公告)日： 2013-02-27
- 发明人: BEUSKER, Patrick, Henry , COUMANS, Rudy, Gerardus, Elisabeth , ELGERSMA, Ronald, Christiaan , MENGE, Wiro, Michaël, Petrus, Bernardus , JOOSTEN, Johannes, Albertus, Frederikus , SPIJKER, Henri, Johannes , DE GROOT, Franciscus, Marinus, Hendrikus
- 申请人： Syntarga B.V.
- 申请人地址： Toernooiveld 1 6525 ED Nijmegen NL
- 专利权人： Syntarga B.V.
- 当前专利权人： Syntarga B.V.
- 当前专利权人地址： Toernooiveld 1 6525 ED Nijmegen NL
- 代理机构： van den Broek, Ludovicus A.G.M.
- 优先权： US421824P 20101210; US326437P 20100421
- 国际公布： WO2011133039 20111027
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61P35/00 ; A61K47/48 ; C07D471/04
摘要：
This invention relates to novel conjugates of the DNA-alkylating agent CC-1065. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The conjugates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the conjugates of this invention may be used to treat a tumor.
公开/授权文献
- EP2560645B1 CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS 公开/授权日：2016-07-13
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