发明公开
- 专利标题： ISOTOPE PREPARATION METHOD
- 专利标题（中）： 用于生产ISOTOP
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申请号： EP11719186.6申请日： 2011-04-29
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公开(公告)号： EP2564396A1公开(公告)日： 2013-03-06
- 发明人: KARLSON, Jan, Roger , BØRRETZEN, Peer
- 申请人： Algeta ASA
- 申请人地址： P.O.Box 54 Kjelsås 0411 Oslo NO
- 专利权人： Algeta ASA
- 当前专利权人： Algeta ASA
- 当前专利权人地址： P.O.Box 54 Kjelsås 0411 Oslo NO
- 代理机构： Goddard, Christopher Robert
- 优先权： GB201007354 20100430
- 国际公布： WO2011134671 20111103
- 主分类号： G21G1/00
- IPC分类号： G21G1/00 ; A61K51/02
摘要：
The present invention provides a method for the generation of
223 Ra of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprising
227 Ac,
227 Th and
223 Ra; ii) loading said generator mixture onto a strong base anion exchange resin; iii) eluting said
223 Ra from said strong base anion exchange resin using a first mineral acid in an alcoholic aqueous solution to give a first eluted
223 Ra solution; iv) loading the
223 Ra of the first eluted
223 Ra solution onto a strong acid cation exchange resin; and v) eluting the
223 Ra from said strong acid cation exchange resin using a second mineral acid in aqueous solution to provide a second eluted solution. The invention additionally provides products of corresponding purity and/or products obtained or obtainable by such a method.
223 Ra of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprising
227 Ac,
227 Th and
223 Ra; ii) loading said generator mixture onto a strong base anion exchange resin; iii) eluting said
223 Ra from said strong base anion exchange resin using a first mineral acid in an alcoholic aqueous solution to give a first eluted
223 Ra solution; iv) loading the
223 Ra of the first eluted
223 Ra solution onto a strong acid cation exchange resin; and v) eluting the
223 Ra from said strong acid cation exchange resin using a second mineral acid in aqueous solution to provide a second eluted solution. The invention additionally provides products of corresponding purity and/or products obtained or obtainable by such a method.
公开/授权文献
- EP2564396B1 ISOTOPE PREPARATION METHOD 公开/授权日：2015-05-20
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