发明公开
EP2564832A1 Solid dosage form of HIV protease inhibitors
审中-公开
Feste Dosierungsformen von HIV-Proteaseinhibitoren
- 专利标题: Solid dosage form of HIV protease inhibitors
- 专利标题(中): Feste Dosierungsformen von HIV-Proteaseinhibitoren
-
申请号: EP11179139.8申请日: 2011-08-29
-
公开(公告)号: EP2564832A1公开(公告)日: 2013-03-06
- 发明人: Rother, Patrick , Fischer, Diana , Täubrich, Theresa , Oppelt, Renate
- 申请人: Hexal AG
- 申请人地址: Industriestrasse 25 83607 Holzkirchen DE
- 专利权人: Hexal AG
- 当前专利权人: Hexal AG
- 当前专利权人地址: Industriestrasse 25 83607 Holzkirchen DE
- 代理机构: Gravert, Maike
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61K31/426 ; A61K31/513
摘要:
A pharmaceutical dosage form suitable for oral administration comprising a solid dispersion of at least one HIV protease inhibitor, at least one first pharmaceutically acceptable water-soluble polymer (A), at least one second pharmaceutically acceptable water-soluble polymer (B), and optionally at least one pharmaceutically acceptable surfactant,wherein the at least one first pharmaceutically acceptable water-soluble polymer (A) has a glass transition temperature (Tg) of at least 50°C and is present in an amount of 10% to 49% by weight of the dosage form and is not polyvinylpyrrolidone (PVP) or hydroxypropyl methylcellulose (HPMC), and wherein the at least one second pharmaceutically acceptable water-soluble polymer (B) has a Tg of less than 50°C.
信息查询