发明公开
EP2571510A1 BIOSYNTHETIC PROLINE/ALANINE RANDOM COIL POLYPEPTIDES AND THEIR USES
有权
BIOSYNTHETISCHE PROLIN- / ALANIN-RANDOM-COIL-POLYPEPTIDE
- 专利标题： BIOSYNTHETIC PROLINE/ALANINE RANDOM COIL POLYPEPTIDES AND THEIR USES
- 专利标题（中）： BIOSYNTHETISCHE PROLIN- / ALANIN-RANDOM-COIL-POLYPEPTIDE
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申请号： EP11725656.0申请日： 2011-05-20
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公开(公告)号： EP2571510A1公开(公告)日： 2013-03-27
- 发明人: SKERRA, Arne , BINDER, Uli , SCHLAPSCHY, Martin
- 申请人： XL-protein GmbH , Technische Universität München
- 申请人地址： Lise-Meitner-Strasse 30 85354 Freising DE
- 专利权人： XL-protein GmbH,Technische Universität München
- 当前专利权人： XL-protein GmbH,Technische Universität München
- 当前专利权人地址： Lise-Meitner-Strasse 30 85354 Freising DE
- 代理机构： Vossius & Partner
- 优先权： US201061428016P 20101229; EP10163564 20100521
- 国际公布： WO2011144756 20111124
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K7/00
摘要：
We discovered that a biosynthetic polypeptide, consisting of at least about 50 proline (Pro) and alanine (Ala) amino acid residues, forms a random coil, and increases the stability of other compounds to which it is conjugated, such as small molecules and polypeptides. We describe such biosynthetic polypeptides, constructs containing such polypeptides, ways of making them, and their use.
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