发明公开
- 专利标题： INHIBITORS OF HUMAN 12-LIPOXYGENASE
- 专利标题（中）： 人12-脂氧合酶抑制剂的
-
申请号： EP11721629.1申请日： 2011-05-18
-
公开(公告)号： EP2571853A1公开(公告)日： 2013-03-27
- 发明人: MALONEY, David J. , HOLMAN, Theodore , JADHAV, Ajit , SIMEONOV, Anton , BANTUKALLU, Ganesha Rai , NADLER, Jerry L. , HOLINSTAT, Michael
- 申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services , The Regents of the University of California , Eastern Virginia Medical School , Thomas Jefferson University
- 申请人地址： Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325, MSC 7660 Bethesda, MD 20892-7660 US
- 专利权人： The U.S.A. as represented by the Secretary, Department of Health and Human Services,The Regents of the University of California,Eastern Virginia Medical School,Thomas Jefferson University
- 当前专利权人： The U.S.A. as represented by the Secretary, Department of Health and Human Services,The Regents of the University of California,Eastern Virginia Medical School,Thomas Jefferson University
- 当前专利权人地址： Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325, MSC 7660 Bethesda, MD 20892-7660 US
- 代理机构： Pfenning, Meinig & Partner GbR
- 优先权： US345708P 20100518
- 国际公布： WO2011146618 20111124
- 主分类号： C07D215/28
- IPC分类号： C07D215/28 ; C07D215/38 ; C07D405/06 ; C07D409/06 ; A61K31/47 ; A61K31/4709 ; A61K31/496 ; A61P3/10 ; A61P9/00
摘要：
Disclosed are inhibitors of human 12-lipoxygenase of Formula (I) or (II), wherein R
1 , R
2 , R
3 , and R
4 are as defined herein, that are useful in treating or preventing a 12-lipoxygenase mediated disease or disorder, e.g., diabetes. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal.
1 , R
2 , R
3 , and R
4 are as defined herein, that are useful in treating or preventing a 12-lipoxygenase mediated disease or disorder, e.g., diabetes. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal.
信息查询
