发明公开
EP2582833A1 ENZYMATIC RESOLUTION OF RACEMIC (2R,S)-2-(ACETYLAMINO)-3-METHOXY-N-(PHENYLMETHYL)PROPANAMIDE
审中-公开
的外消旋酶拆分（2R，S）-2-（乙酰基氨基）-3-甲氧基-N-（苯基甲基）丙酰胺
- 专利标题： ENZYMATIC RESOLUTION OF RACEMIC (2R,S)-2-(ACETYLAMINO)-3-METHOXY-N-(PHENYLMETHYL)PROPANAMIDE
- 专利标题（中）： 的外消旋酶拆分（2R，S）-2-（乙酰基氨基）-3-甲氧基-N-（苯基甲基）丙酰胺
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申请号： EP11736163.4申请日： 2011-06-15
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公开(公告)号： EP2582833A1公开(公告)日： 2013-04-24
- 发明人: BOSCH I LLADO, Jordi , DURAN LOPEZ, Ernesto
- 申请人： Medichem, S.A.
- 申请人地址： Fructuós Gelabert 6-8 Sant Joan Despi 08970 Barcelona ES
- 专利权人： Medichem, S.A.
- 当前专利权人： Medichem, S.A.
- 当前专利权人地址： Fructuós Gelabert 6-8 Sant Joan Despi 08970 Barcelona ES
- 代理机构： Gallafent, Antony Xavier
- 优先权： US201161434149P 20110119; US354961P 20100615
- 国际公布： WO2011158194 20111222
- 主分类号： C12P13/02
- IPC分类号： C12P13/02
摘要：
The present invention is concerned with a process of preparing (R)-lacosamide. The process comprises providing an (R,S)-lacosamide precursor and contacting the same with at least an enzyme in the presence of a solvent. The enzyme either stereoselectively hydrolyzes or acetylates an (R)- or (S)-enantiomer of the (R,S)-lacosamide precursor. The process further comprises where appropriate also concurrently, or successively, employing one or more reagents capable of converting the hydrolysed or acetylated (R)- or (S)-enantiomer to (R)- lacosamide.
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