发明公开
EP2591795A1 RNA targeting compounds and methods for making and using same
有权
RNA-Target-Verbindungen und Verfahren zu ihrer Herstellung und Verwendung
- 专利标题: RNA targeting compounds and methods for making and using same
- 专利标题(中): RNA-Target-Verbindungen und Verfahren zu ihrer Herstellung und Verwendung
-
申请号: EP12178045.6申请日: 2008-02-25
-
公开(公告)号: EP2591795A1公开(公告)日: 2013-05-15
- 发明人: Disney, Matthew D.
- 申请人: The Research Foundation Of State University Of New York
- 申请人地址: Office of Science Technology Transfer & Economic Outreach Intellectual Property Division UB Technology Incubator, Suite 111 Baird Research Park 1576 Sweet Home Road Amherst, NY 14228 US
- 专利权人: The Research Foundation Of State University Of New York
- 当前专利权人: The Research Foundation Of State University Of New York
- 当前专利权人地址: Office of Science Technology Transfer & Economic Outreach Intellectual Property Division UB Technology Incubator, Suite 111 Baird Research Park 1576 Sweet Home Road Amherst, NY 14228 US
- 代理机构: Steinecke, Peter
- 优先权: US903212P 20070223; US4389P 20071127
- 主分类号: A61K38/16
- IPC分类号: A61K38/16
摘要:
Disclosed are RNA targeting compounds having the formula : wherein j is an integer from 1 to 100; each i is the same or different and is zero or an integer from 1 to 100; each Z 1 represents the same or different linking moiety; each R 1 is the same or different and represents an alkyl group or an aryl group; each Q 1 represents the same or different RNA binding ligand; Q 2 is an alkyl group; Q 3 is a halogen, an alkyl group, an aryl group, or an amine. Also disclosed are RNA targeting compounds that include a polymer backbone and two or more pendant RNA binding ligands that are bound to the polymer backbone. Methods for using the subject RNA targeting compounds to treat myotonic dystrophy and other diseases are also disclosed, as are compounds that can be used to prepare the subject RNA targeting compounds.
公开/授权文献
信息查询
IPC分类: