发明公开
EP2596017A4 CROSS-PROTECTIVE PATHOGEN PROTECTION, METHODS AND COMPOSITIONS THEREOF
审中-公开
保护，禁止交叉反应的病原体及方法及其组合物
- 专利标题： CROSS-PROTECTIVE PATHOGEN PROTECTION, METHODS AND COMPOSITIONS THEREOF
- 专利标题（中）： 保护，禁止交叉反应的病原体及方法及其组合物
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申请号： EP11809104申请日： 2011-07-22
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公开(公告)号： EP2596017A4公开(公告)日： 2014-03-19
- 发明人: SCHRADER JOHN W
- 申请人： SCHRADER JOHN W
- 专利权人： SCHRADER JOHN W
- 当前专利权人： SCHRADER JOHN W
- 优先权： US36674710 2010-07-22
- 主分类号： C07K16/10
- IPC分类号： C07K16/10 ; A61K39/00 ; A61K39/145 ; A61K39/295 ; A61P31/16 ; A61P37/04 ; C12P21/08 ; C12Q1/70
摘要：
The present disclosure provides a method of inducing a cross-protective immune response in a subject against a pathogen, such as influenza, comprising administering a first unique pathogen antigen to the subject; and administering a second unique pathogen antigen 3-52 weeks after a); wherein the second unique pathogen antigen and the first unique pathogen antigen are immunologically distinct but share conserved sites that are not normally immunogenic for antibodies. Also disclosed herein are assays for detecting cross-protective antibodies, methods of generating novel cross-protective antibodies. Further provided are novel antibodies against influenza.
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