发明公开
EP2597097A1 SUBSTITUTED INDOLES, ANTIVIRAL ACTIVE COMPONENT, METHOD FOR PRODUCING AND USING SAME
审中-公开
替代品INDOLE,ANTIVIRALER WIRKSTOFF,HERSTELLUNGS- UND VERWENDUNGSVERFAHRENDAFÜR
- 专利标题: SUBSTITUTED INDOLES, ANTIVIRAL ACTIVE COMPONENT, METHOD FOR PRODUCING AND USING SAME
- 专利标题(中): 替代品INDOLE,ANTIVIRALER WIRKSTOFF,HERSTELLUNGS- UND VERWENDUNGSVERFAHRENDAFÜR
-
申请号: EP11809940.7申请日: 2011-07-19
-
公开(公告)号: EP2597097A1公开(公告)日: 2013-05-29
- 发明人: BICHKO, Vadim Vasilievich , MITKIN, Oleg Dmitrievich , IVACHTCHENKO, Alexandre Vasilievich
- 申请人: Alla Chem, LLC. , Limited Liability Company "MIP-11"
- 申请人地址: 318 N. Carson Street, Suite 208 Carson City NV 89701 US
- 专利权人: Alla Chem, LLC.,Limited Liability Company "MIP-11"
- 当前专利权人: Alla Chem, LLC.,Limited Liability Company "MIP-11"
- 当前专利权人地址: 318 N. Carson Street, Suite 208 Carson City NV 89701 US
- 代理机构: Henrion, Oliver
- 优先权: RU2010130863 20100723
- 国际公布: WO2012011847 20120126
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; C07D401/06 ; C07D401/14 ; C07D209/82 ; C07D209/88 ; A61K31/496 ; A61K31/498 ; A61K31/5517 ; A61K31/454 ; A61K31/437 ; A61K9/48 ; A61K9/20 ; A61K9/08 ; A61P31/12
摘要:
The invention relates to novel antiviral active components of the general formula 1, pharmaceutical composition, antiviral medicament, method for prophylaxis and treatment of viral diseases, particularly caused by hepatisis C viruses (HCV). In the general formula 1
R1 represents hydrogen, optionally substituted C 1 -C 4 alkyl, C 6 cycloalkyl, aryl, ethoxycarbonyl, nitro group; R2 represents hydrogen; R3 represents N -mono-or N,N -disubstituted 1-methylene-piperidine-3-carboxamide of the general formula 1a or N -mono- or N,N -disubstituted 1-methylene-piperidine-4-carboxamide of the general formula 1b; R4 represents hydrogen, optionally substituted C 1 -C 3 alkyl; or R2 and R3 together with the C-atoms they are attached to form substituted ,3,4,9-tetrahydro-1 H -carbazole of the general formula 1.1, or R2, R3, and R4 together with the atoms they are attached to form substituted azaheterocycles of the eneral formula 1.2; R5 and R6 optionally identical represent hydrogen, optionally substituted C 1 -C 3 alkyl or C 3 -C 6 cydoalkyl, or R5 and R6 together with the N-atom they are attached to form optionally substituted 5- or 6- membered azaheterocyclyl comprising one or two N-atoms and optionally condensed with benzene ring;
R7 and R8 represent hydrogen or R7 and R8 together with the C-atom they are attached to form C=O group; R9 represents azaheterocyclyl comprising at least one N-atom, unsubstituted formamide, or phenyl substituted with ethoxycarbonyl or nitro group; R10 represents hydrogen, optionally substituted C 1 -C 3 alkyl, substituted acetyl; n = 1 or 2; solid line accompanied by the dotted line, i.e. ( ), represents single or double C-C bond.
R1 represents hydrogen, optionally substituted C 1 -C 4 alkyl, C 6 cycloalkyl, aryl, ethoxycarbonyl, nitro group; R2 represents hydrogen; R3 represents N -mono-or N,N -disubstituted 1-methylene-piperidine-3-carboxamide of the general formula 1a or N -mono- or N,N -disubstituted 1-methylene-piperidine-4-carboxamide of the general formula 1b; R4 represents hydrogen, optionally substituted C 1 -C 3 alkyl; or R2 and R3 together with the C-atoms they are attached to form substituted ,3,4,9-tetrahydro-1 H -carbazole of the general formula 1.1, or R2, R3, and R4 together with the atoms they are attached to form substituted azaheterocycles of the eneral formula 1.2; R5 and R6 optionally identical represent hydrogen, optionally substituted C 1 -C 3 alkyl or C 3 -C 6 cydoalkyl, or R5 and R6 together with the N-atom they are attached to form optionally substituted 5- or 6- membered azaheterocyclyl comprising one or two N-atoms and optionally condensed with benzene ring;
R7 and R8 represent hydrogen or R7 and R8 together with the C-atom they are attached to form C=O group; R9 represents azaheterocyclyl comprising at least one N-atom, unsubstituted formamide, or phenyl substituted with ethoxycarbonyl or nitro group; R10 represents hydrogen, optionally substituted C 1 -C 3 alkyl, substituted acetyl; n = 1 or 2; solid line accompanied by the dotted line, i.e. ( ), represents single or double C-C bond.
信息查询