A SCCA-1 production inhibitor, comprising as an active ingredient, at least one carboxyamide derivative selected from the group consisting of compounds represented by the following formula (I):

wherein X is CR 5 or N, R 1 , R 4 and R 5 each independently represent hydrogen, C 1 -C 4 alkyl or a C 1 -C 6 hydroxyalkyl group having 1-5 hydroxy groups, R 2 and R 3 each independently represent hydrogen, C 1 -C 4 alkyl or a C 1 -C 6 hydroxyalkyl group having 1-5 hydroxy groups, or each represents a group -(CH 2 ) n -, wherein n represents an integer of 1 or 2, and may form a 5- to 6-membered ring together with the atoms to which they are bonded and with the carbonyl group, allantoin, and salts thereof.