发明公开
EP2604280A2 Compositions and methods for inhibiting PDGFRBETA and VEGF-A
审中-公开
用于抑制PDGFRBETA和VEGF-A的组合物和方法
- 专利标题： Compositions and methods for inhibiting PDGFRBETA and VEGF-A
- 专利标题（中）： 用于抑制PDGFRBETA和VEGF-A的组合物和方法
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申请号： EP13159556.3申请日： 2009-03-27
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公开(公告)号： EP2604280A2公开(公告)日： 2013-06-19
- 发明人: Sivakumar, Pallavur V. , Gilbertson, Debra G. , Snavely, Marshall D. , Mabry, George R. , Yi, Eugene C. , Yao, Yue , Presnell, Scott R.
- 申请人： ZymoGenetics, Inc.
- 申请人地址： 1201 Eastlake Avenue East Seattle, Washington 98102 US
- 专利权人： ZymoGenetics, Inc.
- 当前专利权人： ZymoGenetics, Inc.
- 当前专利权人地址： 1201 Eastlake Avenue East Seattle, Washington 98102 US
- 代理机构： Griffin, Philippa Jane
- 优先权： US40068P 20080327; US144547P 20090114
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P35/00 ; C07K16/22 ; C07K16/28
摘要：
There is provided an isolated antibody that binds to the extracellular domain of PDGFRβ and neutralizes PDGFRβ activity, said antibody comprising a V L domain comprising CDRs LCDR1, LCDR2, and LCDR3 and a V H domain comprising CDRs HCDR1, HCDR2, and HCDR3, wherein:
LCDR1 has the amino acid sequence shown in SEQ ID NO: 433, optionally the amino acid sequence shown in SEQ ID NO: 443;
LCDR2 has the amino acid sequence shown in SEQ ID NO: 434;
LCDR3 has the amino acid sequence shown in SEQ ID NO: 435, optionally the amino acid sequence shown in SEQ ID NO: 444;
HCDR1 has the amino acid sequence shown in SEQ ID NO: 436, optionally the amino acid sequence shown in SEQ ID NO: 445;
HCDR2 has the amino acid sequence shown in SEQ ID NO: 437;
HCDR3 has an amino acid sequence selected from the group consisting of SEQ ID NOs: 438-442
LCDR1 has the amino acid sequence shown in SEQ ID NO: 433, optionally the amino acid sequence shown in SEQ ID NO: 443;
LCDR2 has the amino acid sequence shown in SEQ ID NO: 434;
LCDR3 has the amino acid sequence shown in SEQ ID NO: 435, optionally the amino acid sequence shown in SEQ ID NO: 444;
HCDR1 has the amino acid sequence shown in SEQ ID NO: 436, optionally the amino acid sequence shown in SEQ ID NO: 445;
HCDR2 has the amino acid sequence shown in SEQ ID NO: 437;
HCDR3 has an amino acid sequence selected from the group consisting of SEQ ID NOs: 438-442
公开/授权文献
- EP2604280A3 Compositions and methods for inhibiting PDGFRBETA and VEGF-A 公开/授权日：2013-10-16
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