发明公开
EP2606907A1 Optineurin-derived polypeptides, their nucleic acids and uses thereof
审中-公开
Optineurinabgeleitete Polypeptide，derenNucleinsäurenund Verwendungen davon
- 专利标题： Optineurin-derived polypeptides, their nucleic acids and uses thereof
- 专利标题（中）： Optineurinabgeleitete Polypeptide，derenNucleinsäurenund Verwendungen davon
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申请号： EP11306702.9申请日： 2011-12-19
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公开(公告)号： EP2606907A1公开(公告)日： 2013-06-26
- 发明人: Weil, Robert, Serge , Kachaner, David , Côrte-Real Filipe, Josina , Laplantine, Emmanuel, François , Israël, Alain
- 申请人： Institut Pasteur , Centre National de la Recherche Scientifique , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
- 申请人地址： 25-28 rue du Docteur Roux 75724 Paris Cédex 15 FR
- 专利权人： Institut Pasteur,Centre National de la Recherche Scientifique,UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
- 当前专利权人： Institut Pasteur,Centre National de la Recherche Scientifique,UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
- 当前专利权人地址： 25-28 rue du Docteur Roux 75724 Paris Cédex 15 FR
- 代理机构： Desaix, Anne
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K14/435
摘要：
The invention relates to Optineurin-derived polypeptide(s) consisting of a polypeptidic sequence disclosed in SEQ ID N°2, which represents the portion of the wild-type human Optineurin protein sequence from its amino-acid residue 131 to its amino-acid residue 297, or having a polypeptidic sequence encompassing the polypeptidic sequence disclosed in SEQ ID N°2, or having a polypeptidic sequence derived from the polypeptidic sequence disclosed in SEQ ID N°2 to the exclusion of the wild-type Optineurin protein. The polypeptide(s) of the invention retain one, any combination of two, or three of the following functional properties: the capacity to bind Rab8 protein, when the latter are associated with the Golgi apparatus of a cell, the capacity to bind MYPT1 protein, when said protein is engaged in a Myosin-Phosphatase (MP) complex, the capacity to be phosphorylated by Plk1. The invention also relates to nucleic acid molecule(s) encoding such polypeptide(s), vector(s) and method(s) of production thereof, as well as uses thereof, in particular uses in treating cancer(s) or in treating a disease involving mitosis deregulation(s) or alteration(s).
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