发明公开
- 专利标题： PLEUROMUTILIN DERIVATIVES FOR USE IN THE TREATMENT OF DISEASES MEDIATED BY MICROBES
- 专利标题（中）： 富兰克林堡德克萨斯州立大学维克登堡
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申请号： EP11751528.8申请日： 2011-08-11
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公开(公告)号： EP2614049A1公开(公告)日： 2013-07-17
- 发明人: RIEDL, Rosemarie , THIRRING, Klaus , HEILMAYER, Werner
- 申请人： Nabriva Therapeutics AG
- 申请人地址： Leberstrasse 20 1110 Wien AT
- 专利权人： Nabriva Therapeutics AG
- 当前专利权人： Nabriva Therapeutics AG
- 当前专利权人地址： Leberstrasse 20 1110 Wien AT
- 代理机构： Schwarz & Partner
- 优先权： EP10450143 20100909
- 国际公布： WO2012031307 20120315
- 主分类号： C07C323/52
- IPC分类号： C07C323/52 ; A61K31/215 ; A61P31/00
摘要：
Compounds selected from the group ofN-unsubstituted or N-alkylated or N-acylated 14-O-[(amino(C 0-4 )alkyl-hydroxy-cycloalkyl- or bicycloalkylsulfanyl)-acetyl]-mutilins which are 14-O-[(amino(C 0-4 )alkyl-hydroxy-cyclobutylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C 0-4 )alkyl-hydroxy-cyclopentylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C 0-4 )alkyl-hydroxy-cycloheptylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C 0-4 )alkyl-hydroxy-cyclooctylsulfanyl)-acetyl]-mutilins, or 14-O-[(amino(C 0-4 )alkyt-hydroxy-bicycloalkylsulfanyl)-acetyl]-mutilins, optionally in the form of a salt and/or a solvate, a pharmaceutical compositions comprising such compounds and their use as pharmaceuticals, e.g. for the treatment of microbial infections and for the treatment of acne, optionally in combination with other pharmaceutically active agents.
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