- 专利标题： ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS
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申请号： EP11831345.1申请日： 2011-09-29
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公开(公告)号： EP2621526B1公开(公告)日： 2018-06-06
- 发明人: SATPAEV, Daulet , MORRISON, Robert, Kendall , MORRISON, Karen Jane, Meyrick , GUDAS, Jean , JAKOBOVITS, Aya , TORGOV, Michael , AN, Zili
- 申请人： Agensys, Inc. , Seattle Genetics, Inc.
- 申请人地址： 2225 Colorado Avenue Santa Monica, CA 90404 US
- 专利权人： Agensys, Inc.,Seattle Genetics, Inc.
- 当前专利权人： Agensys, Inc.,Seattle Genetics, Inc.
- 当前专利权人地址： 2225 Colorado Avenue Santa Monica, CA 90404 US
- 代理机构： Bezzubova, Olga
- 优先权： US387933P 20100929
- 国际公布： WO2012047724 20120412
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; C07K16/30 ; A61N5/10 ; A61K39/00
摘要：
Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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