发明公开
EP2628727A2 Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders
审中-公开
Biaryl-PDE4-Inhibitoren zur Behandlung von Lungen- und Herz-Kreislauferkrankungen
- 专利标题： Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders
- 专利标题（中）： Biaryl-PDE4-Inhibitoren zur Behandlung von Lungen- und Herz-Kreislauferkrankungen
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申请号： EP13000709.9申请日： 2008-11-20
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公开(公告)号： EP2628727A2公开(公告)日： 2013-08-21
- 发明人: Singh, Jasbir , Gurney, Mark , Burgin, Alex , Kiselyov, Alexander , Rao, Munagala , Hagen, Timothy
- 申请人： Decode Genetics EHF
- 申请人地址： Sturlugata 8 101 Reykjavik IS
- 专利权人： Decode Genetics EHF
- 当前专利权人： Decode Genetics EHF
- 当前专利权人地址： Sturlugata 8 101 Reykjavik IS
- 代理机构： Graf von Stosch, Andreas
- 优先权： US989551P 20071121
- 主分类号： C07D207/16
- IPC分类号： C07D207/16 ; C07D213/64 ; C07D213/79 ; C07D231/12 ; C07D239/42 ; C07D401/06 ; C07D471/04 ; C07D473/18 ; C07D473/40 ; C07D285/135 ; C07D213/06 ; C07D213/74 ; C07D213/75 ; C07D213/84 ; C07D401/04 ; C07D233/90 ; C07D275/06
摘要：
The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula Ia, Ib, Ic or Id:
or salt thereof, in particular a pharmaceutically acceptable salt thereof.
or salt thereof, in particular a pharmaceutically acceptable salt thereof.
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