发明公开
- 专利标题： CANCER IMAGING WITH THERAPY: THERANOSTICS
- 专利标题（中）： 具有治疗癌症成像：治疗诊断
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申请号： EP11837147.5申请日： 2011-10-28
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公开(公告)号： EP2633063A2公开(公告)日： 2013-09-04
- 发明人: POMPER, Martin, Gilbert , BHANG, Hyo-eun , FISHER, Paul
- 申请人： Virginia Commonwealth University , The Johns Hopkins University
- 申请人地址： 800 E. Leigh Street Suite 113 Richmond, VA 23298-0568 US
- 专利权人： Virginia Commonwealth University,The Johns Hopkins University
- 当前专利权人： Virginia Commonwealth University,The Johns Hopkins University
- 当前专利权人地址： 800 E. Leigh Street Suite 113 Richmond, VA 23298-0568 US
- 代理机构： Kröncke, Rolf
- 优先权： US407714P 20101028
- 国际公布： WO2012058522 20120503
- 主分类号： C12Q1/04
- IPC分类号： C12Q1/04 ; G01N33/52 ; C12N15/86 ; C12N5/10 ; A01K67/027 ; C12N5/09
摘要：
Genetic constructs comprising reporter genes operably linked to cancer specific or cancer selective promoters (such as the progression elevated gene-3 (PEG-3) promoter) are provided, as are methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. Transgenic animals in which a reporter gene is linked to a cancer specific or cancer selective promoter, and which may be further genetically engineered, bred or selected to have a predisposition to develop cancer, are also provided.
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