发明公开
- 专利标题： ANTIBODIES TO TUMOR ENDOTHELIAL MARKER 8
- 专利标题（中）： 抗体对肿瘤内皮细胞标记物8
-
申请号： EP11840238.7申请日： 2011-11-14
-
公开(公告)号： EP2637692A2公开(公告)日： 2013-09-18
- 发明人: FRANKEL, Arthur E. , SU, Yunpeng , ST. CROIX, Brad , LEPPLA, Stephen H.
- 申请人： Scott & White Healthcare , The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services , Wake Forest University School Of Medicine
- 申请人地址： 2401 South 31st Street Temple, TX 76508 US
- 专利权人： Scott & White Healthcare,The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services,Wake Forest University School Of Medicine
- 当前专利权人： Scott & White Healthcare,The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services,Wake Forest University School Of Medicine
- 当前专利权人地址： 2401 South 31st Street Temple, TX 76508 US
- 代理机构： Roberts, Joanne Nicola
- 优先权： US201161527339P 20110825; US412999P 20101112
- 国际公布： WO2012065161 20120518
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The present invention is directed to particular antibodies and fragments thereof that find use in the detection, prevention and treatment of diseases and disorders associated with abnormal angiogenesis. In particular, these antibodies detect tumor endothelial marker 8 (TEM8) in its native and cell-surface expressed form. Also disclosed are improved methods for producing monoclonal antibodies, as well as pharmaceutical compositions and kits.
信息查询
