发明公开
EP2639240A2 Peptides able to impair the inhibiting activity of MDM2/MDM4 heterodimer towards p53 and use thereof for cancer treatment
有权
肽影响了MDM2 / MDM4异源二聚体对p53的活性的抑制，并使用它们用于治疗癌症
- 专利标题： Peptides able to impair the inhibiting activity of MDM2/MDM4 heterodimer towards p53 and use thereof for cancer treatment
- 专利标题（中）： 肽影响了MDM2 / MDM4异源二聚体对p53的活性的抑制，并使用它们用于治疗癌症
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申请号： EP13155985.8申请日： 2013-02-20
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公开(公告)号： EP2639240A2公开(公告)日： 2013-09-18
- 发明人: Pellegrino, Marsha , Moretti, Fabiola , Mancini, Francesca , Macchiarulo, Antonio , Pelliciari, Roberto
- 申请人： Consiglio Nazionale Delle Ricerche , Universita Degli Studi Di Perugia
- 申请人地址： Piazzale Aldo Moro, 7 00185 Roma IT
- 专利权人： Consiglio Nazionale Delle Ricerche,Universita Degli Studi Di Perugia
- 当前专利权人： Consiglio Nazionale Delle Ricerche,Universita Degli Studi Di Perugia
- 当前专利权人地址： Piazzale Aldo Moro, 7 00185 Roma IT
- 代理机构： Gitto, Serena
- 优先权： ITRM20120060 20120221
- 主分类号： C07K14/47
- IPC分类号： C07K14/47
摘要：
The present invention concerns peptides able to impair the inhibiting activity of MDM2/MDM4 heterodimer towards p53 and maintain the association between MDM4 and p53 so to restore the p53 oncosuppressive function in cancer cells harboring wild type p53 protein, directing its function specifically towards an apoptotic outcome.
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