发明公开
EP2639240A3 Peptides able to impair the inhibiting activity of MDM2/MDM4 heterodimer towards p53 and use thereof for cancer treatment
有权
能够削弱MDM2 / MDM4异二聚体对p53的抑制活性的肽及其在癌症治疗中的用途
- 专利标题： Peptides able to impair the inhibiting activity of MDM2/MDM4 heterodimer towards p53 and use thereof for cancer treatment
- 专利标题（中）： 能够削弱MDM2 / MDM4异二聚体对p53的抑制活性的肽及其在癌症治疗中的用途
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申请号： EP13155985.8申请日： 2013-02-20
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公开(公告)号： EP2639240A3公开(公告)日： 2013-12-04
- 发明人: Pellegrino, Marsha , Moretti, Fabiola , Mancini, Francesca , Macchiarulo, Antonio , Pelliciari, Roberto
- 申请人： Consiglio Nazionale Delle Ricerche , Universita Degli Studi Di Perugia
- 申请人地址： Piazzale Aldo Moro, 7 00185 Roma IT
- 专利权人： Consiglio Nazionale Delle Ricerche,Universita Degli Studi Di Perugia
- 当前专利权人： Consiglio Nazionale Delle Ricerche,Universita Degli Studi Di Perugia
- 当前专利权人地址： Piazzale Aldo Moro, 7 00185 Roma IT
- 代理机构： Gitto, Serena
- 优先权： ITRM20120060 20120221
- 主分类号： C07K14/47
- IPC分类号： C07K14/47
摘要：
The present invention concerns peptides able to impair the inhibiting activity of MDM2/MDM4 heterodimer towards p53 and maintain the association between MDM4 and p53 so to restore the p53 oncosuppressive function in cancer cells harboring wild type p53 protein, directing its function specifically towards an apoptotic outcome.
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